The U.S. Food and Drug Administration amended the emergency use authorization (EUA) for the Pfizer-BioNTech COVID-19 vaccine to expand the use of a single booster dose to include use in individuals from 12 to 15.
The agency announced in a news release that they also would shorten the time between the completion of primary vaccination of the Pfizer-BioNTech COVID-19 Vaccine and a booster dose to at least five months.
Additionally, the FDA said it would allow for a third primary series dose for certain immunocompromised children ages 5 through 11.
“Throughout the pandemic, as the virus that causes COVID-19 has continuously evolved, the need for the FDA to quickly adapt has meant using the best available science to make informed decisions with the health and safety of the American public in mind,” Acting FDA Commissioner Janet Woodcock, M.D, said in a news release.
“With the current wave of the omicron variant, it’s critical that we continue to take effective, life-saving preventative measures such as primary vaccination and boosters, mask wearing and social distancing to in order to effectively fight COVID-19.”
Dr. Woodcock said the FDA determined that the protective health benefits of a single booster dose of the Pfizer-BioNTech COVID-19 Vaccine to provide continued protection against COVID-19 and the associated serious consequences that can occur including hospitalization and death, outweigh the potential risks in individuals aged 12 through 15.
The FDA said it reviewed real-world data from Israel, including safety data from more than 6,300 individuals aged 12 through 15 who received a booster dose of the vaccine at least five months following completion of the primary two-dose vaccination series.
“These additional data enabled the FDA to reassess the benefits and risks of the use of a booster in the younger adolescent population in the setting of the current surge in COVID-19 cases,” the agency noted in the news release.
The FDA said data shows there are no new safety concerns following a booster in this population. There were no new cases of myocarditis or pericarditis reported to date in these individuals.
The FDA also authorized the use of a single booster dose five months after completion of the primary vaccination series of the Pfizer-BioNTech COVID-19 Vaccine.
“Since Pfizer initially submitted safety and effectiveness data on a single booster dose following primary vaccination, additional real-world data have become available on the increasing number of cases of COVID-19 with the omicron variant in the U.S.,” agency officials wrote.
No new safety concerns have emerged from a population of over 4.1 million individuals 16 years of age and older in Israel who received a booster dose at least five months following completion of the primary vaccination series, the release continued.
Additionally, they said peer-reviewed data from multiple laboratories indicate that a booster dose of the Pfizer-BioNTech COVID-19 Vaccine greatly improves an individual’s antibody response to be able to counter the Omicron variant.
“Authorizing booster vaccination to take place at five months rather than six months may therefore provide better protection sooner for individuals against the highly transmissible Omicron variant,” the FDA noted.
“Given the demonstrated safety and effectiveness of a booster dose when administered five months after the primary vaccination series, and the fact that a booster dose may help provide better protection against the rapidly spreading omicron variant, the FDA has determined that the known and potential benefits of administering a booster to individuals ages 12 and older at least five months following completion of the primary vaccination series, outweighs the known and potential risks.”
While today’s action applies to the Pfizer-BioNTech COVID-19 Vaccine, the FDA said it continues to review data concerning all available vaccines and will provide additional updates as appropriate.
Children five through 11, who have undergone solid organ transplantation, or who have been diagnosed with conditions that are considered to have an equivalent level of immuno-compromise, may not respond adequately to the two-dose primary vaccination series, researchers contend.
Thus, a third primary series dose has now been authorized for that group.
“This will now allow these children to receive the maximum potential benefit from vaccination,” according to the agency.
The FDA previously authorized a third primary series dose for use as part of the primary immunization series in individuals 12 years and older.
They agency said the potential effectiveness of an additional dose in children five through 11 years of age was extrapolated from data in adults.
Researchers used prior analyses conducted as part of the authorization process for healthy children to inform safety in this population and determined that the potential benefits of the administration of a third primary series dose at least 28 days following the second dose of the two-dose regimen, outweighed the potential and known risks of the vaccine. To date, the FDA and CDC have seen no new safety signals in this age group.
Children five through 11, who are fully vaccinated and are not immuno-compromised do not need a third dose at this time, but the FDA said it would continue to review information and communicate with the public if data emerges suggesting booster doses are needed for this pediatric population.
“Based on the FDA’s assessment of currently available data, a booster dose of the currently authorized vaccines may help provide better protection against both the delta and omicron variants. In particular, the Omicron variant appears to be slightly more resistant to the antibody levels produced in response to the primary series doses from the current vaccines,” said Peter Marks, M.D., Ph.D., director of the FDA’s Center for Biologics Evaluation and Research.
“With this in mind, the FDA has extended the range of individuals eligible to receive a booster, shortened the length of time between the completion of the Pfizer primary series for individuals to receive a booster and is authorizing a third protective vaccine dose for some of our youngest and most vulnerable individuals.”